Skip to NavigationSkip to content

Novo Nordisk delivers in much-anticipated oral semaglutide diabetes trial

Published on 23/02/18 at 09:53am

Novo Nordisk has lifted the curtain on much-anticipated results data from the first of ten Phase 3 trials into the efficacy of semaglutide when administered as a once-daily oral tablet in the treatment of type 2 diabetes in adults.

The study utilised two distinct criteria for assessing the drug’s efficacy, evaluating endpoints both taking into account and disregarding patient adherence to the medication. 703 participants were randomised to receive one of three doses of the drug: 3mg, 7mg or 14mg, while another group received placebo.

The findings reported that the trial met its primary endpoint, demonstrating “significant and superior improvements” in HbA1C(long-term blood sugar) compared to placebo in all three dose groups. These reductions, when patients adhered to treatment, were recorded as 0.8% in the 3mg group, 1.3% in the 7mg group, and 1.5mg in the 14mg group. In the same groups, 59%, 72% and 80% respectively achieved the American Diabetes Association target of below 7% HBA1C, compared to just 34% with placebo.

Additionally, the 14mg dose showed significant weight-loss benefits, recording reductions of 4.1kg compared to1.5kg with placebo.

“We are very encouraged by the results of the PIONEER 1 trial, which confirm the unprecedented oral efficacy of semaglutide that was reported in the phase 2 clinical trial in type 2 diabetes," said Mads Krogsgaard Thomsen, Executive Vice President and Chief Science Officer of Novo Nordisk. "We look forward to providing data from the remaining nine PIONEER trials throughout this year and an expected regulatory submission in 2019.”

Matt Fellows

Mission Statement
Pharmafile.com is a leading portal for the pharmaceutical industry, providing industry professionals with pharma news, pharma events, pharma service company listings and pharma jobs,
Site content is produced by our editorial team exclusively for Pharmafile.com and our industry newspaper Pharmafocus. Service company profiles and listings are taken from our pharmaceutical industry directory, Pharmafile, and presented in a unique Find and Compare format to ensure the most relevant matches