Novartis’ two cancer drugs get NICE backing as combination treatment for skin cancer

pharmafile | April 29, 2016 | News story | Medical Communications NICE, Novartis, combination therapy, regulation, skin cancer 

The National Institute for Health and Care Excellence (NICE) on Friday backed a combination therapy for skin cancer comprising two drugs from the Swiss drug firm Novartis (VTX: NOVN).

The regulator has recommended a combination therapy with Mekinist (trametinib) and Tafinlar (dabrafenib), saying the treatment could extend life by six months.

The NHS will pay a reduced price for the drugs after a discount was agreed between the company and the Department of Health. The list price of trametinib with dabrafenib per patient per 28 days is 10,080 pounds.

Professor Carole Longson, Health Technology Evaluation Centre Director at NICE, said: “This combination treatment is the latest in a line of promising new drugs for advanced melanoma we have recommended that look set to significantly extend the life of people with the condition. I know from testimonies presented to the committee that patients and healthcare professionals alike will welcome this positive recommendation.”

Patients with BRAF V600 mutation positive melanoma receiving the new treatment in two clinical trials survived an average of 6 months longer than those on other drugs.

Life expectancy for those with advanced melanoma is currently under two years. Melanoma accounted for around 1,750 deaths in 2012 in England, and 12,200 people were diagnosed in 2013.

In February NICE recommended nivolumab (Opdivo, Bristol Myers Squibb) for advanced melanoma.

NICE has also issued two separate recommendations each for ipilimumab (YERVOY, Bristol-Myers Squibb) and pembrolizumab (Keytruda, Merck Sharp & Dohme) for advanced melanoma.

Anjali Shukla

Related Content

Novo Nordisk launches Wegovy in the UK

Novo Nordisk has today announced that Wegovy (semaglutide injection) is now available in the UK …

Amicus Therapeutics’ Pompe disease treatment approved for use in UK

Amicus Therapeutics has announced that the Medicines and Healthcare products Regulatory Agency (MHRA) in the …

NICE shares draft guidance for AI’s use in radiotherapy treatment planning

The National Institute for Health and Care Excellence (NICE) has shared draft guidance surrounding nine …

Latest content