Novartis’ CAR T therapy Kymriah nails main goal in follicular lymphoma
pharmafile | August 4, 2020 | News story | Manufacturing and Production, Research and Development | CAR-T therapy, Cancer, Kymriah, Novartis, car t therapy
Novartis is celebrating the success of its one-time CAR T therapy Kymriah (tisagenlecleucel) in patients with relapsed or refractory (r/r) follicular lymphoma (FL), revealing that the therapy met its primary its primary endpoint of complete response rate (CRR) in Phase 2 trials, according to an independent review committee.
The findings are significant for a treatment of this stature. Kymriah was the first CAR T therapy to secure approval from the FDA, and is currently authorised for use in the treatment of acute lymphoblastic leukaemia (ALL) and r/r adult diffuse large B-cell lymphoma (DLBCL) in patients up to 25 years of age.
The company said it continues to expand its manufacturing capacity for the therapy as it closes in on a third approved indication, with seven facilities across four continents contributing to the production of the drug worldwide.
“We are pleased that Kymriah is showing meaningful results and may provide a potentially definitive treatment option for patients with relapsed and refractory follicular lymphoma,” remarked Dr John Tsai, Head of Global Drug Development and Chief Medical Officer at Novartis. “These results further support our efforts to reimagine medicine in this incurable malignancy and reach this underserved patient population, who are historically burdened with several years of various treatments.”
Novartis confirmed that full results from the study would be revealed at a future medical event and that the data will be submitted to US and European regulators.
Matt Fellows
Related Content
Novartis receives SMC approval for early breast cancer treatment
Novartis has announced that its treatment for early breast cancer, Kisqali (ribociclib), has received approval …
Novartis candidate for Sjögren’s disease presents positive results
Novartis has reported positive results from two phase 3 clinical trials – NEPTUNUS-1 and NEPTUNUS-2 …
Central nervous system cancer metastases – the evolution of diagnostics and treatment
The current forms of immunotherapy, how T cell therapy works and what the future holds
