Innate Pharma shares results from phase 1/2 trial for blood cancer treatment

Betsy Goodfellow | June 17, 2024 | News story | Research and Development Innate Pharma, Oncology, blood cancer, clinical trial 

Innate Pharma has announced updated efficacy and safety results from the dose-escalation part of the phase 1/2 study with SAR443579/IPH6101 (SAR’579), from a joint research collaboration between Innate and Sanofi.

The compound is an investigational CD123 targeting NKp46/CD16-based Natural Killer Cell Engager (NKCE), and has US Food and Drug Administration (FDA) Fast Track Designation for the treatment of acute myeloid leukaemia.

The results have been shared during an oral presentation at the European Hematology Association 2024 Congress in Madrid, Spain on Saturday 16 June 2024.

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The trial assessed SAR’579 as a monotherapy for the treatment of blood cancers with high unmet needs, such as relapsed or refractory acute myeloid leukaemia (R/R AML), B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk myelodysplasia (HR-MDS).

Dr Sonia Quaratino, chief medical officer of Innate Pharma, commented: “We are pleased to see that SAR’579 continues to show promising and durable clinical efficacy along with a favorable safety profile. The ongoing phase 1/2 study has recently progressed to the phase 2 stage, marking a significant milestone in its development. We look forward to the continued progress of this multi-specific NK Cell Engager which holds great potential to benefit patients suffering from various blood cancers.”

Betsy Goodfellow

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