AbbVie’s Rinvoq impresses at Phase 3 in active psoriatic arthritis sub-population
pharmafile | October 31, 2019 | News story | Research and Development | AbbVie, Rinvoq, pharma
AbbVie has unveiled new Phase 3 data on two doses of its JAK inhibitor Rinvoq (upadacitinib), showing that the therapy met its primary endpoint in the treatment of active psoriatic arthritis in adult patients who have responded inadequately to one or more biologic disease modifying anti-rheumatic drugs (bDMARDs).
The data revealed that both 15mg and 30mg formulations generated an ACR20 response on the American College of Rheumatology’s measure of the disease in 57% and 64% of patients respectively, following 12 weeks of treatment compared to 24% with placebo. Furthmore, 32% and 38% of patients receiving these dosages achieved ACR50 compared to 5% with placebo, and 9% and 17% scored ACR70 versus 0.5% of placebo patients.
The study also noted that Rinvoq patients also reported greater improvements in physical function after 12 weeks according to the Health Assessment Questionnaire Disability Index, and 52% and 57% of patients reported 75% improvement in skin symptoms on the Psoriasis Area Severity Index after 16 weeks compared to 16% with placebo.
The study also met all of its ranked secondary endpoints compared to placebo.
“Too many people living with psoriatic arthritis still fail to achieve their treatment goals, underscoring a clear medical need for additional therapeutic options,” said Dr Michael Severino, Vice Chairman and President at AbbVie. “We are pleased with these data, which show the potential of Rinvoq to improve outcomes for people with psoriatic arthritis across a variety of symptoms. Data from this Phase 3 study will support regulatory submissions for Rinvoq in psoriatic arthritis.”
The company confirmed it would present the full results of the study at an upcoming medical conference.
Matt Fellows
Related Content
Medincell and AbbVie enter agreement for development of next-generation injectables
Medincell and AbbVie have announced that they have entered into a collaboration to co-develop and …
AbbVie to acquire Landos Biopharma for approximately $137.5m
AbbVie and Landos Biopharma have announced that they have entered into a definitive agreement under …
AbbVie and Tentarix collaborate on oncology and immunology treatments
AbbVie and Tentarix Biotherapeutics have announced that they have entered a multi-year collaboration focused on …
