ANGLE’s Parsortix system used in new cancer biology research

Ella Day | June 10, 2025 | News story | Medical Communications, Research and Development |  Angle, Oncology, Parsortix system, R&D, biotech, oncology, scientific journals 

ANGLE has announced three new peer-reviewed publications demonstrating the use of its Parsortix circulating tumour cell (CTC) harvesting system in studies exploring cancer biology and therapeutic targets. The research, led by academic groups in Germany, Ireland and the US, supports the system’s growing role in advancing oncology R&D.

In one study, published in Journal of Experimental & Clinical Cancer Research, Klaus Pantel’s team at University Medical Center Hamburg-Eppendorf, Germany, used Parsortix to detect both cancerous and healthy cell release into the bloodstream during prostatectomy surgery. The findings raise questions about the risks of intraoperative tumour dissemination.

Meanwhile, researchers at Trinity College Dublin, Ireland, writing in the European Journal of Surgical Oncology, applied the system to rare epithelial ovarian carcinomas. Their work revealed higher CTC yields from local tumour veins compared to peripheral veins, including in early-stage patients – suggesting early systemic spread may occur sooner than expected.

A third paper from the Cleveland Clinic, US, published in Cancers, explored biomechanical cell changes associated with metastasis in breast cancer. Using RNA-sequenced CTCs isolated through Parsortix, the study linked increasing ‘mechanical conditioning scores’ with metastatic progression, potentially informing future anti-fibrotic drug therapeutics.

“We are proud to see ANGLE’s technology increasingly being used to make novel discoveries into the biology of cancer, which may eventually result in new treatment strategies,” said Karen Miller, ANGLE’s chief scientific officer.

Ella Day
10/6/25