Skip to NavigationSkip to content

New depression treatment relieves sleep problems in patients

Published on 12/04/05 at 03:39pm

An innovative new depression drug has shown improved benefits over existing treatments, according to data presented by its manufacturer Servier.

Valdoxan (agomelatine) is the first melatonergic agonist antidepressant, a new class of drug for the treatment of depression.

The once-daily tablet has a unique mode of action and works by acting on circadian rhythms, which are often imbalanced in depressed patients.

New data, presented at the 13th Congress of the Association of European Psychiatrists, showed the drug to be effective in improving disrupted sleep patterns of depressed patients without affecting daytime vigilance.

"Agomelatine is an interesting and potentially very valuable antidepressant that is effective in both moderate and severe depression," commented Professor Stuart Montgomery, Imperial College School of Medicine in London.  

"The new agent has a unique mode of action, improves sleep without affecting daytime alertness and its efficacy is not compromised by sexual side-effects, tolerability problems or discontinuation symptoms.

The data was the result of an eight week placebo-controlled trial which showed Valdoxan to be an effective antidepressant at a dose of 25mg.

Further results showed the treatment had a similar efficacy to Wyeth's Efexor (venlafaxine), with patients taking Valdoxan showing significantly less sexual dysfunction than those taking Wyeth's drug.

Valdoxan was recently submitted to the EMEA for approval with additional phase III trials now in progress. 

Related articles: 

New depression treatment launched in the UK 

Thursday , February 03, 2005

 

 

 

Mission Statement
Pharmafile.com is a leading portal for the pharmaceutical industry, providing industry professionals with pharma news, pharma events, pharma service company listings and pharma jobs,
Site content is produced by our editorial team exclusively for Pharmafile.com and our industry newspaper Pharmafocus. Service company profiles and listings are taken from our pharmaceutical industry directory, Pharmafile, and presented in a unique Find and Compare format to ensure the most relevant matches