Skip to NavigationSkip to content

Keytruda/chemo combo recommended for first-line lung cancer via Cancer Drugs Fund

Published on 08/08/19 at 10:37am

MSD’s Keytruda (pembrolizumab) has secured recommendation from NICE for inclusion on the Cancer Drugs Fund (CDF) in combination with chemotherapy in the first-line treatment of untreated metastatic squamous non-small cell lung cancer (NSCLC), it has emerged.

The final appraisal determination marks the first for a immunotherapy/chemotherapy combo in this indication regardless of PD-L1 expression. The ruling stipulates that the combo should only be used in patients who have stopped at two years of uninterrupted treatment with Keytruda, or earlier in the event of disease progression.

The decision was reached based on Phase 3 data which showed that the combo imrpved overall survival by 15.9 months compared to 11.3 months and reduced the risk of death by 36% when compared to chemotherapy alone. Additionally, the combo extended progression free survival by 44%, while the objective response rate was 57.9% compared to chemo alone.

“It is of great and lasting importance that we will now be able to offer patients with advanced squamous non-small cell lung cancer (NSCLC), the combination of chemotherapy plus pembrolizumab as a first line treatment option,” remarked Professor Gary Middleton, Professor of Medical Oncology at the University of Birmingham. “Progress in the first line treatment of this cancer has been frustratingly slow and, until this time, there has not been any agent which, when added to chemotherapy, provides really robust and clinically meaningful benefits over chemotherapy alone. The addition of pembrolizumab significantly improves overall survival compared to chemotherapy alone and, importantly, across all strata of tumour cell PD-L1 expression. The combination of pembrolizumab and chemotherapy in eligible patients with advanced squamous NSCLC should now become the first line standard of care and the benchmark for future first line studies in this disease.”

Louise Houson, UK Managing Director at MSD, said: “We are pleased that following this approval the majority of lung cancer patients now have access to some form of immunotherapy, including those patients with particularly hard to treat forms of this disease. We have, as ever, worked collaboratively with NHS England and NICE to ensure the value of pembrolizumab in combination with chemotherapy is recognised. Enabling access to the first immunotherapy/chemotherapy combination for this form of lung cancer in the first line setting will make a real difference to patients. We hope that this continues as we look to bring more indications to market in the near future.”

Matt Fellows

Comments

Great survey, I'm sure you're getting a great response. business consultant

Thanks for a wonderful share. Your article has proved your hard work and experience you have got in this field. Brilliant .i love it reading. sos notary

Thanks for the blog post buddy! Keep them coming... nj real estate listings

I am definitely enjoying your website. You definitely have some great insight and great stories. Couples psychologist Newport beach

I read that Post and got it fine and informative. Please share more like that... Omni Centers

The information you have posted is very useful. The sites you have referred was good. Thanks for sharing.. canal iptv

Thanks for sharing this useful info.. boho wedding dresses

Your website is really cool and this is a great inspiring article. Thank you so much. DJs in Atlanta

Your music is amazing. You have some very talented artists. I wish you the best of success. Pest Control CT

I am hoping the same best effort from you in the future as well. In fact your creative writing skills has inspired me. situs judi bola terbesar

thanks this is good blog. indonesia diving

Its a great pleasure reading your post.Its full of information I am looking for and I love to post a comment that "The content of your post is awesome" Great work. Traditional 401k

This is such a great resource that you are providing and you give it away for free. bridesmaid dresses

The post is written in very a good manner and it contains many useful information for me. budget movers

Thanks for the valuable information and insights you have so provided here... cracker barrel employee complaints

It was a very good post indeed. I thoroughly enjoyed reading it in my lunch time. Will surely come and visit this blog more often. Thanks for sharing. security services in Nottingham

I am unable to read articles online very often, but I’m glad I did today. This is very well written and your points are well-expressed. Please, don’t ever stop writing. Abbotsford Chain link Fencing

Thanks, that was a really cool read! Bonuses

This is such a great resource that you are providing and you give it away for free. cheapest poster printers online

Nice post mate, keep up the great work, just shared this with my friendz Lawyers in Nigeria

Yes i am totally agreed with this article and i just want say that this article is very nice and very informative article.I will make sure to be reading your blog more. You made a good point but I can't help but wonder, what about the other side? !!!!!!THANKS!!!!!! www.liteblue.usps.gov

i was just browsing along and came upon your blog. just wanted to say good blog and this article really helped me. swimming pool tip

Nice post mate, keep up the great work, just shared this with my friendz Holm Law Group San Diego

Please continue this great work and I look forward to more of your awesome blog posts. morgan horse temperament

Thank you a bunch for sharing this with all of us you actually realize what you are talking about! Bookmarked. Please also seek advice from my site =). We could have a hyperlink change contract between us! Swamp Sounds

I am happy to find this post very useful for me, as it contains lot of information. I always prefer to read the quality content and this thing I found in you post. Thanks for sharing. Airplane Noise

Mission Statement
Pharmafile.com is a leading portal for the pharmaceutical industry, providing industry professionals with pharma news, pharma events, pharma service company listings and pharma jobs,
Site content is produced by our editorial team exclusively for Pharmafile.com and our industry newspaper Pharmafocus. Service company profiles and listings are taken from our pharmaceutical industry directory, Pharmafile, and presented in a unique Find and Compare format to ensure the most relevant matches